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  • The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in adults with a body mass index (BMI) greater than 27, provided that they also experience weight-related health issues such as Tupe2 diabestes, high cholesterol levels and/or hypertension (hypertension).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so that as an aid to smoking cessation treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director from the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle including a reduced-calorie eating and working out, Contrave provides another treatment option for chronic weight reduction for people who are obese or are overweight and still have at least one weight-related health.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular exercising. Results from a medical trial that enrolled patients without diabetes showed that patients had the average weight loss of four years old.1% instead of participants who have been given placebos) throughout a 12- month period, while a different study involving patients with type 2 diabetes had the average weight loss of 2% over treatment with placebo at one full year.

    Using two separate drugs to lose weight can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the people who go through it one should err along the side of caution and let the FDA do its job and demand some research be done so your public understands the side effects and dangers of the medications before we drive them. Keep in mind that drug companies come in business to generate income and that they would say almost anything to keep people on his or her medications.

    Researchers found that participants investing in this drug to get a year, dropped excess weight within 4 weeks and have kept the extra weight off through the 56 weeks in the study. Contrave is often a combination from the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which might be made up of multiple active ingredient, that might make them more efficient and safer.

    Combo-pilling may be the newest fad or even better the newest ahead under scrutiny and therefore it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills has become popular is the fact that since right now there aren't long term prescription weight loss supplements that have been approved by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be authorized by the FDA.

    Seizures really are a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug may also raise blood pressure and heart rate, and shouldn't be used in those with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.

    The FDA also warned that Contrave can raise blood pressure and heartbeat and must not used in patients with uncontrolled high hypertension, in addition to by you aren't heart-related and cerebrovascular (blood vessel dysfunction impacting the mind) disease. Patients having a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients on the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation.

    Most of the combinations that are used to enhance fat loss involve an amphetamine with an antidepressant. Phentermine and Prozac really are a popular combination that were around for a long time, and although it has been around nobody wants to truly combine both the and try to get FDA approval to market it as a fat loss pill. Right there should raise some warning flag if the greedy pharmaceutical companies don't want to be involved in combining medications and selling them something must be wrong using the combination. In fairness there is one fat loss combination pill that is in front of the FDA now Contrave?which couples naltrexone, accustomed to treat alcohol and substance abuse, while using antidepressant bupropion (Wellbutrin, Zyban) many experts have given the just do it to move forward by an FDA advisory committee, but by yet has not been approved.